Refine Cancer Diagnosis and Treatment

As HemeOmkLinx reports that researchers at the University of Florida have developed a method of effectively identifying subtle leukemic cell variants, thus enabling the selective detection of malignant cells on a molecular level with a high degree of specificity. Using single-stranded DNA or RNA probes, known as aptamers, these investigators have successfully delineated several subtypes of adult T-cell leukemia. The aptamers are capable of assuming various 3-D conformations which bind expressly with the unique sites of distinctive cancer cell subsets.

As a diagnostic tool, aptamers represent a clear improvement beyond the antibodies typically employed for this purpose, which fail to discriminate at this molecular level between populations of cancer cells. The pairing of specific aptamer binding patterns and corresponding patient data may then allow the individualizing of future cancer treatment strategies. Volume synthesis of aptamers can be done inexpensively.
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